This was to give anyone reading only a tiny fraction of how it feels to wait THREE WEEKS after seeing a PI-RADS score of 4 on my MRI. Yes, I intentionally put off discussing my biopsy results to the end of this article. For the optimist, maybe only a 40% chance or even a bit lower, depending on which study you read and whether or not the physician recommends treatment for Gleason grade 7 cancers. In plain English, based on the MRI results and on various studies I have read over the three longest weeks in my life, I figured I had about a 50-50 chance of having a clinically significant cancer that required some sort of treatment in the near future. PI-RADS 4 lesions also can be benign or less aggressive cancer with a Gleason score of 6 or less. Suffice to say that while a score of 4 does not usually indicate the presence of the most aggressive cancers (Gleason score of 8 or more), it often shows concerning cancers with a Gleason score of 7. On the other hand, a PI-RADS score of 5 is usually bad news and has a much higher correlation to cancer. The correlations for a score of 4 just aren’t as well established yet, and that’s why these studies continue. Thankfully, it seems that a PI-RADS score of 4 isn’t nearly as bad as a score of 5, but on a scale of 1-5, even a 4 feels pretty bad to a patient. There are a number of studies out there showing the correlation of PI-RADS to biopsy results for cancer. These might all be positive considerations for less invasive focal treatments. Plus, there was no indication it had spread beyond the prostate or into any other tissues within the prostate. Making lemonade out of lemons, the fact that only a single lesion was present was relatively good news. Things were not nearly as promising on this one: Ten years ago, I did not have any cancer, nor was any type of lesion or tumor indicated on the MRI. Armed with the MRI results, they were able to precisely target this tumor with two separate biopsy samples from different angles, along with 12 other random cores to see if cancer was present or had spread elsewhere in the prostate. A half-centimeter size lesion was shown on the MRI, and a random biopsy might miss that small of a lesion altogether. On the plus side, it also told me that I was doing the right thing. A score of 4 means that, “Clinically significant cancer is likely to be present.” The modified scale used by the NIH was only slightly better, “Moderately likely for prostate cancer.”Īs you can imagine, it considerably freaked me out to learn this in the hours of worrying while I waited to be taken for my biopsy procedure. For reference, ten years ago, my MRI report score was a PI-RADS 1, or “highly unlikely” to have clinically significant cancer. I was given a PI-RADS score of 4 on a scale of 5, with a 5 being most likely for cancer. Three weeks ago, I was shown my prostate TRUS MRI fusion results.
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As Hades will hit the same area twice, you can easily dodge the second hit by simply dodging to where the first hit of Shadow Spread hit. He will immediately follow up with Shadow Spread, so make sure you assign clock positions beforehand, and spread into them. The fight begins with Hades immediately using Ancient Double, which sets the stage for all of his abilities in this phase, causing them to hit twice. When they fall to the ground, they expand and deal significant magic damage, and also inflict a stack of Vulnerability Up. Broken Faith: Small circle AoEs begin to fall from the sky.Arcane Utterance: Hades will summon a set of orbs or a set of mirrors along the arena.It is a small circle aoe around the tank, so be careful not to get cleaved. Hits twice during Double, so a tank swap is necessary. Ravenous Assault: Tankbuster dealing heavy magical damage, and inflicting a Magic Vulnerability up. The area that's being hit first is the one the spikes are facing. Shortly after, Hades will attack the other 2 quadrants. Bad Faith: Hades summons a wall of spikes to his sides, attacking 2 of 4 quadrants of the arena.The aoe is locked in after the first hit, so players can move to a safe spot to dodge the second hit. Shadow Spread: Magical damage. Hades will target each party member with a cone AoE that originates from his center, so players must spread out into clock positions.Ancient Double: Gives Hades the effect of "Double", causing most attacks in this phase to be preformed twice.The minimum ilvl to enter this fight is i450, but can be bypassed with a full party. The Minstrel's Ballad: Hades's Elegy, also called Hades EX, is a high-end duty added in patch 5.1: Vows of Virtue, Deeds of Cruelty. The fight can be unlocked by speaking to the Minstreling Wanderer in the Crystarium ( 7.5, 12.5 ) after completing the main story quest "Shadowbringers". David Fane – Roquefort Fane – Roquefort David Fane is a famous actor and writer from New Zealand. Tom has a long list of his expeditious work throughout his career. He has voiced Natsu Dragneel from Fairy Tail, Ebony Maw from Marvel Ultimate Alliance 3, Android 19 from Dragon Ball Z Kai, Hiroshi Tameda from My Hero Academia, and Slapback from Ben 10. Todd mostly does English dubs for games and anime series. Todd Haberkorn – Zanzo Todd Haberkorn – Zanzo The famous American voice actor and voice director Todd Haberkorn is an all-time-fav artist of gamers due to his excellent voiceovers. Throughout his career, Sunil has done the voice for many characters, including X-8 Robot Brain, Courier’s Brain, and Muggy in Fallout: New Vegas. Sunil Malhotra – CNMN Malhotra – CNMN Sunil Malhotra is an Indian writer and actor known for his work in various movies, including Halo: Reach, Fair Game, and Where’s the Party Yaar? Besides being a decent actor, he’s a great voice artist as well. Lee has greatly performed her role in Hi-Fi Rush by dubbing accurate vocals according to the personality of Rekka, giving her the perfect negative role. Her famous work includes Star Wars Jedi: Fallen Order, Penn & Teller: Fool Us, and Aggretsuko. Besides being a voice artist, she is also a great actress and producer. Misty Lee – Rekka Lee – Rekka Misty Lee is a senior voice actress who’s from Michigan, USA. Gabe is a well-known artist and also runs his own Tiktok and Youtube channels where he posts humorous stuff and voice dubbing of various characters. Gabe Kunda – Macaron Kunda – Macaron Gabe Kunda is an American voice actor who’s known for voicing in Deca-Dence, Apex Legends (2019), and Code Geass: Lelouch of the Resurrection. Erica has expertise in voice dubbing for game characters, which makes her a perfect fit for the voice of Peppermint. She has also appeared in all time fav game series: God of War Ragnarok. Most recently, she has done the voice of Celica in Fire Emblem Engage and Captain Marvel in Marvel’s Midnight Suns. Her famous work includes the voice acting of Loona from Helluva Boss, Black Cat in the Spider-Man 2018 series, Cassie Cage from Mortal Kombat 11, Meredith from Cyberpunk 2077, and many more. Erica Lindbeck – Peppermint Erica Lindbeck – Peppermint Who doesn’t know Lindbeck, the famous American voice actress who has been the voice of many characters and tv cartoons? Lindbeck is also a tv actress as she has worked in local theatres and a couple of shows after completing her major in acting from UCLA School of Theater, Film, and Television.Įrica has done voice acting for many video games and TV shows. He has also worked with Marvel for voice-over in the animated Spiderman series. His best work includes the voice role of Jesse Cosay in the second season of Infinity Train Goro, Akechi in Persona 5, and Orbulon in WarioWare Gold. He’s known for his roles in different animations, audiobooks, and video games. The voice behind Chai is Robbie Daymond, who is an American voice actor with a pretty decent fan following. The MP3 player gives him musical powers to fight his foes. Robbie Daymond – Chai Robbie Daymond – Chai Chai, who has the leading role in Rush, is a funky character who seems to have robotic body parts with a music player fused with his heart. To do the job, Tango Gameworks hired some talented voice actors. For better character presentation, we can see different voice dubbing for each hero in the game. The game features many characters, each one having its own charisma and personality. The Hi-Fi rush has not failed to deliver a decent quality release with enhanced visuals and interesting features. Check out our long-term Tesla Model Y test page for all the details on how it held up over the duration of our test, how reliable it was, and what it's like to live with the Model Y. Our test team lived with the Model Y and put it through its paces over thousands of miles and months of real-world use. Check out the Expert Rating below to get our test team's full take on the Model Y's utility, comfort, real-world range and more. The Audi Q4 e-tron, Ford Mustang Mach-E, Hyundai Ioniq 5, Kia EV6, Nissan Ariya, Subaru Solterra, Toyota bZ4X and Volkswagen ID.4 are all models that you might also want to consider for your next electric SUV purchase. The Y is undeniably the sales leader in its class, but that class is growing with new options. As of this publication, Tesla has dropped the price of the Model Y several times throughout the year. There's a lot that goes into the new cells, but what matters to most consumers is that this battery technology promises lower costs, which Tesla could pass on to its customers. The new 4680 cells are a complete overhaul of the battery tech inside Tesla's cars, and the company has been working on them for quite some time. Specific to the 2023 Tesla Model Y is the introduction of Tesla's so-called 4680 battery cells. Recent updates include pricing reductions and the introduction of an Enhanced Autopilot option that adds a variety of advanced driver assist features, such as automatic lane changes as well as self-parking and summon features, without having to pay for the full-boat Full Self-Driving upgrade. Unlike most other automakers, Tesla makes rolling updates to its vehicles rather than waiting for a brand-new model year to come around. Official details for the 2023 Model Y will likely keep trickling in throughout the year. Ritual's Essential Prenatal specifically targets 12 key nutrients to support a healthy pregnancy, with transparent ingredient sourcing and rigorous third-party testing. Pregnancy brings unique nutritional needs, so be sure to speak with a healthcare professional before selecting a prenatal vitamin. To make our recommendations, our prenatal dietitian used her experience working with hundreds of pregnant people, and her insight from the latest research, and she consulted other experts in the field. Purity and quality are of utmost concern when it comes to taking supplements during pregnancy. When shopping for your prenatal vitamins, it's important to choose supplements that are made by a trusted brand and, preferably, are third-party tested. Aside from multivitamins, you might need additional supplements-whether you need these will depend on the nutrients your multivitamin is lacking as well as your diet and individual needs. While there is no standard formula for a prenatal multivitamin, they typically contain key nutrients including iron, vitamin D, vitamins A and C, iodine, choline, omega-3 DHA, and B vitamins, including folic acid. The CDC recommends that those of reproductive age who may become pregnant, including those who are pregnant, take 400 micrograms of supplemental folic acid each day in addition to consuming folate-rich foods to prevent neural birth defects in a developing baby. For that reason, they are recommended for those who are pregnant or trying to conceive. While it's important to consume a healthy, balanced diet, prenatal vitamins can help to prevent nutritional deficiencies that can potentially cause pregnancy complications. They include multivitamins and individual supplements that help fill nutrient gaps at a time your nutritional needs are greater. Prenatal vitamins are essential during pregnancy to support both your health and the health of your growing baby. “Sometimes, I think the things I remember are more real than the things I see.” – Arthur Goldenģ4. It’s forgetting that’s hard.” – Brodi Ashtonģ3. “Make sure that your life is full of happy memories in the end.” – Anonymousģ2. They make us laugh when we remember the times we cried, but make us cry when we remember the times we laughed!” – Anonymousģ1. They remain with us forever, like a touchstone.” – Haruki Murakami Good Memories Quotesģ0. But still, no matter how much time passes, no matter what takes place in the interim, there are some things we can never assign to oblivion, memories we can never rub away. “There are just too many things we have to think about everyday, too many new things we have to learn. “Nothing is ever really lost to us as long as we remember it.” – L.M. “Sometimes, things become possible if we want them bad enough.” – T.S. “A moment lasts all of a second, but the memory lives on forever.” – Anonymousġ7. “Things end but memories last forever.” – Kumar Milanġ6. “The real moment has disappeared, but you will always have the memories to remind you.” – Anonymousġ5. “The best thing about memories is making them.” – Anonymousġ4. “It takes one thought, one second, one moment, or positive memory to act as a catalyst for the light to gradually seep in again.” – Fearne Cottonġ3. “You don’t just take a picture with a camera, you take it with your heart.” – Anonymousġ2. “A picture is worth a thousand words, but a memory is priceless.” – Anonymousġ1. So make sure you be a good one.” – Anonymous Unforgettable Memories Quotesġ0. “At some part of life or the other, we all become memories for others. “A moment lasts for seconds, but the memories last forever.” – Anonymousĩ. “I knew that looking back on the tears would make me laugh, but I never knew that looking back on the laughs would bring tears.” – Cat StevensĨ. “We never realize the value of something in our life until it becomes a memory.” – Dr. They make me smile no matter what is going on in my present life.” – AnonymousĦ. “Those sweet memories of my life spent with you are the best. “What I like about photographs is that they capture a moment that’s gone forever, impossible to reproduce.” – Karl Lagerfeldĥ. Memories are sweet, cherish them.” – AnonymousĤ. But you can capture them in your memories forever.” – Anonymousģ. “You may have lost things, persons in your life. Memories need to be shared.” – Lois LowryĢ. “The worst part of holding the memories is not the pain. Think for yourself: Topics that boil down to "Should I watch.", "Will I like.", "Change my view on.", "Does anyone else.", or "Tell me what to think" are not contributing anything to the community. Meta: Send a modmail instead of making public posts or comments about: other users of this subreddit, the rules or moderators, the community at large or other subreddits, downvotes/upvotes.Ĩ. There is no formal spoiler protection for episodes/films after they have been available for approximately one week.ħ. Spoilers: Utilize the spoiler system for any and all spoilers relating to the most recently-aired episodes, as well as previews for upcoming episodes. Don't derail a thread with unrelated comments.Ħ. Compare Star Trek Resurgence Xbox One Download Code and Box Edition prices to buy games online cheaper and play on Xbox Live. Keep on topic: All submissions must be directly about the Star Trek franchise (the shows, movies, books etc.). The Coolest Games We Played At Summer Game Fest 2022. I guide a captain through a tense trade dispute in the Telltale-inspired narrative adventure. Insulting or disparaging remarks about any human being is expressly not allowed.ĥ. Star Trek: Resurgence Preview A Deciding Factor. Just going to pre-order and download it then. Be nice: If a polite way cannot be found to phrase what it is you want to say, don't say anything at all. For Star Trek: Resurgence on the PlayStation 5, a GameFAQs message board topic titled Why are there no. We are not a place for gossip, rumors, or manipulative or misleading content.Ĥ. Previously, the developers of the team have already taken part in the development of various interactive projects in the narrative genre, and. To try and turn it into a game with enough action to be engaging seems out of keeping. Most of Star Trek seems to be largely avoiding major diplomatic incidents. Star Trek Resurgence TrekResurgence STAR TREK: RESURGENCE arrives on Prepare to make your mark on the galaxy in our interactive narrative adventure game where you’re at the heart of an original Star Trek story, and the fate of your crew comes down to your choices 2:00 PM 183. The project is being developed by former employees of Telltale Games, united in a team called Dramatic Labs. There are relatively few big old wars compared to, say, Star Wars which is just decades of continuous civil war, strife and rebellion. Be truthful: All posts/comments must be factually accurate and verifiable. Star Trek: Resurgence is a narrative interactive movie game set in the Star Trek universe. Star Trek Resurgence is being developed and published independently in partnership with Epic Games under license from Paramount. Be welcoming: It is important that everyone from newbies to OG Trekkers feel welcome no matter their gender, sexual orientation, religion or race.ģ. Be constructive: All posts/comments must contribute positively to r/StarTrek and the lives of those who participate here.Ģ. IDW Publishing’s prequel to Star Trek: Resurgence will ramp the anticipation up even further, providing fans with a deep and rich story that touches all corners of the Star Trekuniverse.Click here for the full & detailed guidelinesġ. No exact release date for the game has been set, but as new details continue to be revealed, excitement is building. Whatever the case, Star Trek: Resurgence looks to be a classic in the making, and IDW’s prequel comic will give readers their best look yet at this exciting new game. IDW has more surprises up its sleeve, as solicitations for Resurgence’s second issue make it clear that even more established characters are on their way, including a villain, but the post did not clarify who it would be. 3 Likes Zarcoff April 26, 2023, 5:58pm 3 Yeah I’d love to aswell. Star Trek: Resurgence is a narrative adventure game featuring dialog choices, relationship building, and exploration. Resurgence is steeped in Star Trek history, incorporating “deep-cut” characters and species such as Leah Brahms and the Talarians into its story fans will get to meet Star Trek: Resurgence’s new characters in the prequel comic as well. When can we pre-order the game 5 Likes StarTrek17 April 26, 2023, 5:43pm 2 Hopefully we can preorder soon on Xbox Microsoft store. Star Trek: Resurgence promises to be a Star Trek game unlike any other, with a story touching on all corners of the enduring franchise, and IDW’s prequel comic will give fans their first good look at this exciting new entry. This can be found seven times in the entire document. In the new EU GMP Annex 1, the consideration of first air plays an important part. For PSM, robotized aseptic filling means more than automated processes, so important requirements from the new EU GMP Annex 1 are considered, such as First Air. Thorsten Haefner, Vice President of Business Development, will explain why for a CDMO, responding to their customer requests about manufacturing flexibility has the highest priority and also the current GMP regulatory requirements. One highlight in 2023 is a current case study by PSM GmbH, a CDMO located in Schiffweiler/Germany with their decision for a fully automated robotic aseptic filling line. The Robotic Session during the 2023 ISPE Aseptic Conference in Bethesda, MA on 6-7 March has been established for several years. Restricted Access Barriers Systems (RABS), isolators, robotic systems,should be considered to increase the protection of the product.” For example, in the chapter Principle «Facility, equipment and process should be appropriately designed, qualified and/or validated The use of appropriate technologies (e.g. The new EU GMP Annex 1 also contains important information about robotics. The use of Robots is increasingly investigated to automate these processes as well.įully automated gloveless Robotic Filling Today, due to the new EU GMP Annex 1 (08-25-2022) and its long journey until publication, barrier systems are largely standard in the industry, but even with barrier systems such as RABS (Restricted Access Barrier Systems) or isolators, interventions with gloves are possible or manual tasks are found for components such as Ready to Use RTU’s vials or syringes in tubs. The first ISPE Barrier Conference to address all the risks of the sterile pharmaceutical product took place 32 years ago. The risk of contamination of a sterile product from the environment (room) and the people who do work in it was recognized early on, and this work should be done in a better protective measure. Looking back in history, it was a step-by-step development forward to the current contamination control strategy (CCS) many decades ago. It has been a long journey from the development of primarily manual aseptic processes to fully automated systems that do not require manual intervention. The three stages of life - infancy, adulthood and old age.The three periods of time - past, present and future.The three basic elements - air, water and fire.The Three Stages of the Universe - Creation, Preservation and Destruction.
Use a traditional 2-Deck interface with or without video mixing controls, or layer in your mix with one of the included 4-Deck skins. BPM beat-sync, looping, key-lock, hot cue points, filters and effects all work flawlessly whether youíre mixing audio or blending music videos.Īdvanced Media File Browser With Search, Playlists And AutomixĭEX 3 includes an advanced media file browser for all your music, music videos and karaoke files. The included library filters allow you to view only the file type you want to work with, and the fast search feature displays results as you type. Create custom playlists or generate lists from directories on your hard drive. Album art and color coding makes it easy to find the song/s you’re looking for. Playlist playback automation is built right in engage Automix or Shuffle Play if you need a break.ĭJ Controllers provide hands-on tactile control over PCDJ DEX, allowing for more creativity while mixing. Over 65 DJ controllers from popular DJ equipment manufacturers are natively supported, which means zero-configuration for you so you can get into the mix right away. When you press a button, twist a knob or scratch a platter on your DJ controller PCDJ will react immediately, without latency. Let us show you how! We’ve released a series of DEX tutorial videos that cover the basics all the way up to more advanced DJ mixing software functionality. |
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